Kronos and YabaSanshiro Issues - any thoughts? Trying to run on my GPD Win 2 and PC

I have a GPD Win 2 and a pretty nice PC and having issues with both Kronos and YabaSanshiro on these devices, wondering if anyone can help me out?

General Info:
- Windows 10 64 bit pro OS
- Trying Kronos 1.5.0, YabaSanshiro 2.2.0 (both seem to be latest versions)
- Enable "Bios Emulation" (have also tried using actual Bios files

Issue(s):
- Seems like both emulators give error message, "Can't Initialize Yabause" and once I see this I am hosed. I go to the C:\Users[\MyUser\AppData\Local folder and remove "yabause" folder. I also delete emulator folder, but seems like it's permanently messed up
- I've tried enabling and disabling bios emulation with little effect.

Biggest issues seem to happen when I attempt to play Shinobi X (or Legions, or Shin Shinobi Den, any regions version). Wondering if I have bad files for this game or something?

Any tips or tricks on getting these emulators running smoothly?

Thanks!